Plant biology: Coding in non-coding RNAs - Nature.com


Nature.com

Plant biology: Coding in non-coding RNAs
Nature.com
The discovery of peptides encoded by what were thought to be non-coding – or 'junk' – regions of precursors to microRNA sequences reveals a new layer of gene regulation. These sequences may not be junk, after ... Nonetheless, the fate of any full ...

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The long non-coding RNA HOTTIP promotes progression and gemcitabine ... - 7thSpace Interactive (press release)


The long non-coding RNA HOTTIP promotes progression and gemcitabine ...
7thSpace Interactive (press release)
Methods: High-throughput microarrays were performed to detect the expression profiles of lncRNAs and messenger RNAs in eight human PDAC tissues and four pancreatic tissues. Quantitative real-time PCR was used to determine the levels of HOTTIP and ...

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Cancer whole-genome sequencing: present and future - Nature.com


Cancer whole-genome sequencing: present and future
Nature.com
The human genome contains genes encoding ~20 000 ncRNAs, including transfer RNA, ribosomal RNA, microRNA and other long non-coding RNAs (Figure 3). These functional ncRNAs are expected to contribute to epigenetics, transcription regulation, RNA ...

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Too many targets: Scientists create model to analyze ceRNA regulation ... - Phys.Org


Phys.Org

Too many targets: Scientists create model to analyze ceRNA regulation ...
Phys.Org
"In mammalian cells, each type of miRNA can interact with dozens to hundreds of target RNA species – including protein-coding mRNAs, long non-coding RNAs and recently-discovered circular RNAs." Moreover, he explains, each RNA species can also ...

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Public Release: 19-Mar-2015 UCSF team finds key to making neurons from stem ... - EurekAlert (press release)


Public Release: 19-Mar-2015 UCSF team finds key to making neurons from stem ...
EurekAlert (press release)
Pnky is one of a number of newly discovered long noncoding RNAs (lncRNAs), which are stretches of 200 or more nucleotides in the human genome that do not code for proteins, yet seem to have a biological function. The name, pronounced "Pinky," was ...

and more »

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Kraepelin revisited: schizophrenia from degeneration to failed regeneration - Nature.com


Kraepelin revisited: schizophrenia from degeneration to failed regeneration
Nature.com
TCF4 messenger RNA is upregulated in schizophrenia patients and in patient-derived human-induced pluripotent stem cell neurons when compared with controls. Thus ... Vice versa, long-term depression-like plasticity was reduced after 1 Hz repetitive ...

and more »

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Hey, "These Sequences May Not Be Junk, After All"! Nature and Heredity Report ... - Discovery Institute


Discovery Institute

Hey, "These Sequences May Not Be Junk, After All"! Nature and Heredity Report ...
Discovery Institute
A "News & Views" piece in Nature, "Coding in non-coding RNAs," states: "The discovery of peptides encoded by what were thought to be non-coding -- or 'junk' -- regions of precursors to microRNA sequences reveals a new layer of gene regulation. These ...

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Blood Test for Lung Cancer as First-line Screen Before LDCT - Medscape


Medscape

Blood Test for Lung Cancer as First-line Screen Before LDCT
Medscape
The use of low-dose CT (LDCT) as a screening tool for lung cancer has been criticized for its high cost and its feasibility, given the large number of long-time heavy smokers and ex-smokers and the complexity of the process. What if a less expensive ...

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